EXHIBIT 32.1


CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report of Aethlon Medical, Inc. on Form
10-KSB for the fiscal year ended March 31, 2008 as filed with the Securities and
Exchange Commission on the date hereof, I, James A. Joyce, Chief Executive
Officer and Chief Accounting Officer of the Company, certify, pursuant to 18
U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley
Act of 2002, that:

1. Based on my knowledge, the Annual Report fully complies with the
requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934,
as amended, and

2. The information contained in such Annual Report on Form 10-KSB
fairly presents, in all material respects, the financial condition and results
of operations of Aethlon Medical, Inc.

Date: July 15, 2008

By: /s/ James A. Joyce
-----------------------
James A. Joyce
Chief Executive Officer and Chief Accounting Officer

A signed original of this written statement required by Section 906, or other
document authenticating, acknowledging, or otherwise adopting the signature that
appears in typed form within the electronic version of this written statement
required by Section 906, has been provided to Aethlon Medical, Inc. and will be
retained by Aethlon Medical, Inc. and furnished to the Securities and Exchange
Commission or its staff upon request.